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PULSe Home > Training Groups > Molecular Signaling and Cancer Biology

Molecular Signaling and Cancer Biology

Molecular Signaling and Cancer Biology

Research Includes

  • Apoptosis
  • Cancer Biology
  • Cell Cycle
  • Cell Differentiation
  • Cell Proliferation
  • Chemokines
  • Growth Factors
  • Lipid Mediators
  • Oncogenes
  • Phosphoproteomics
  • Protein Kinases
  • Protein Phosphatases
  • Protein Phosphorylation
  • Signal Transduction
  • Suppressor Genes
  • Therapeutic Targets in Cancer
  • Transcription Factors

  • Training Group Mission

    The mission of the Molecular Signaling and Cancer Biology Training Group is to educate the next generation of biomedical scientists in the understanding of the basic processes of molecular signal transduction. This knowledge will be applied to the study of differentiation, development, apoptosis and growth of normal and abnormal (malignant) cells and the treatment of disease states, with a special emphasis on cancer. The group encourages and facilitates development of integrated, interdisciplinary approaches by promoting interactions with faculty representing research areas such as cancer biology, cancer pharmacology, biomedical engineering, and chemical biology. The Training Group provides opportunities for development of independent and critical thinking skills by fostering participation in scientific seminars and research forums and will provide specialized graduate courses in the areas of Signal Transduction and the Molecular Basis of Cancer. These opportunities provide students with a strong foundation in biochemistry, molecular and cellular biology, and cancer biology preparing them for a wide range of career opportunities in academia and industry.

    Faculty Membership

    Faculty Research Area
    Aguilar, Ruben Claudio Protein trafficking and membrane transport in relation to the processes of cell polarity establishment and carcinogenic transformation
    Andrisani, Ourania M. Transcription factor CREB (cAMP-response-element binding protein) in mechanisms of growth control and cellular differentiation
    Borch, Richard F. Anticancer drugs: design, synthesis, and mechanisms of action
    Briggs, Scott D. Role of histone methylation in gene expression and oncogenesis
    Chang, Henry Membrane trafficking; molecular genetics; cell polarity; development; signal transduction
    Charbonneau, Harry Mitotic function and regulation of the cdc14 protein phosphatase
    Fleet, James C. Regulation of mineral metabolism, molecular actions of vitamin D in calcium metabolism and cancer prevention, gene-environment interactions influencing bone/calcium metabolism or cancer
    Freeman, Jennifer L. Environmental and molecular toxicology, cytogenetics, and genomics
    Geahlen, Robert L. Regulation of signal transduction through the Syk protein-tyrosine kinase
    Gibbs, Richard A. Medicinal and bioorganic chemistry, synthesis and mechanistic evaluation of anticancer drugs
    Hall, Mark C. Regulation of the cell cycle by ubiquitin-dependent proteolysis; protein mass spectrometry
    Hannon, Kevin M. Investigations into treatments and interventions for skeletal muscle atrophy
    Harrison, Marietta L. Understanding the signaling molecule Lck
    Hazbun, Tony Functional genomics and systems biology
    Hrycyna, Christine A. Multidrug resistance in human cancer
    Hu, Chang-Deng AP-1 in human cancers and C. elegans development
    Kim, Chang H. Immunology and hematopoiesis
    Kim, Kee-Hong Regulation of adipocyte development and function by dietary components and cellular stress signaling pathway
    Kirchmaier, Ann L. Epigenetic processes that mediate heritable modifications to chromatin
    Kirshner, Julia Properties of the cancer stem cells using the model systems multiple myeloma and breast cancer
    Konieczny, Stephen F. Gene expression during mammalian development; cancer model systems
    Kuang, Shihuan Stem cell biology; Muscle development and regeneration
    Lelièvre, Sophie A. Understanding how the cell nucleus directs expression and stability of the genome and how tissue architecture influences nuclear organization. Identify tissue architectural factors (notably apical polarity) that contribute to cancer development.
    Liu, Xiaoqi Roles of Polo-like kinase 1 and its interacting proteins in cell proliferation and carcinogenesis
    Low, Philip S. Development of targeted therapic and imaging agents for cancer and various inflammatory diseases. Function and molecular organization of the human red blood cell membrane. Novel methods for detection of human pathogens.
    Mendrysa, Susan M. Oncogenes, delineating the critical components of the signaling pathways in which oncogenes are involved
    Parker, Laurie L. Chemical biology and proteomics to develop biosensors for intracellular phosphorylation signaling
    Post, Carol B. Computational chemistry and biological NMR
    Prasad, Nagendra K. Cell signaling mechanisms regulated by phosphoinositide second messengers relevant to Cancer, Type 2 Diabetes and energy balance.
    Ratliff, Timothy L. Microbial pathogenesis; host-parasite interactions; molecular detection and differentiation of microbial pathogens; recombinant and DNA vaccines
    Regnier, Fred E. Systems for the analysis and characterization of complex protein mixtures using multidimensional separation systems and mass spectrometry
    Riese, David J. ErbB receptor signal transduction in human malignancies
    Rossie, Sandra S. Signal transduction and protein Ser/Thr phosphatases
    Rundell, Ann E. Control of cellular processes, systems biology, computational cell biology, cardiovascular resuscitation
    Shah, Kavita Identification of the substrates of protein kinases, interplay between kinases and the activation and recruitment of downstream effector proteins
    Stauffacher, Cynthia V. Macromolecular structure and assembly using X-ray crystallography; membrane associated proteins; enzyme structure and function
    Szymanski, Daniel The cell signaling and cytoskeletal basis of plant growth mechanisms in model and crop species
    Tao, W. Andy Proteomics and biological mass spectrometry
    Taparowsky, Elizabeth J. Oncogene expression in eukaryotic cells
    Teegarden, Dorothy Vitamin D and cancer Vitamin D and calcium regulation of body composition
    Tran, Elizabeth J The Mechanism of Nuclear Messenger RNA Export
    Umulis, David M Signal transduction in development; mechanisms of robustness, cell fate decisions, and tissue patterning by morphogen gradients
    Van Etten, Robert L. Chemical details underlying the mechanisms of enzymatic catalysis


    Student Membership

    Training Groups are topic-oriented research groups consisting of faculty from multiple departments. Training groups are an administrative home for PULSe students, a student choice that impacts curriculum and research training activities.

     

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