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PULSe Home > Training Groups > Membrane Biology

Membrane Biology

Membrane Biology

Research Includes

  • Beta-glucan Synthases
  • Bioenergetics
  • Cell to Cell Communication
  • Cell Wall Synthesis
  • Cellular Energetics
  • Cellulose Synthases
  • Exo/Endocytosis
  • Flip-Flop
  • Glycoprotein Synthesis
  • Glycosyl Transferases
  • Golgi Apparatus
  • Lateral Diffusion
  • Lipid Trafficking
  • Membrane Dynamics
  • Membrane Microdomains
  • Membrane Proteins
  • Membrane-Associated Enzymes
  • Phase Behavior
  • Plant Membranes
  • Plant Polysaccharide Synthesis
  • Protein Trafficking
  • Protein-Lipid Interactions
  • Signaling Platforms
  • Transmembrane Transport

  • Training Group Mission

    Students in the Membrane Biology training group are educated in the basic and fundamental understanding of cell membranes, their components and how membrane and membrane-associated processes control numerous cellular functions. In addition, students are involved in the transfer of these discoveries into new therapies, biofunctional materials, beneficial agricultural products, and devices for the treatment of human disease. Students work with a multidisciplinary group of faculty from many departments who employ an extensive range of experimental approaches including biochemistry, neurobiology, molecular biology, structural biology, microscopy, biophysical chemistry, analytical and organic chemistry, and engineering. The study of membranes and membrane proteins is a burgeoning and exciting frontier in the life sciences and recent technical advances in the field make significant progress and discovery possible. Students also have the opportunity to interact with other members of the program through seminar courses and research meetings.

    Faculty Membership

    Faculty Research Area
    Aguilar, Ruben Claudio Protein trafficking and membrane transport in relation to the processes of cell polarity establishment and carcinogenic transformation
    Buhman, Kimberly K. Intestinal lipid metabolism, nutritional biochemistry and physiology, heart disease, obesity
    Chang, Henry Membrane trafficking; molecular genetics; cell polarity; development; signal transduction
    Chen, Jue ABC transporters and membrane fusion proteins
    Cheng, Ji-Xin Linear and nonlinear optical microscopy to study how molecules work inside a living cell
    Chmielewski, Jean A. Development of small molecules, peptides and peptidomimetics for drug discovery, bionanotechnology, and cellular delivery of therapeutic agents
    Cramer, William A. Membrane biochemistry, biophysics; structure-function of membrane proteins
    Davidson, Amy L Mechanism of transmembrane transport at the molecular level
    Gibbs, Richard A. Medicinal and bioorganic chemistry, synthesis and mechanistic evaluation of anticancer drugs
    Harrison, Marietta L. Understanding the signaling molecule Lck
    Hrycyna, Christine A. Multidrug resistance in human cancer
    Low, Philip S. Development of targeted therapic and imaging agents for cancer and various inflammatory diseases. Function and molecular organization of the human red blood cell membrane. Novel methods for detection of human pathogens.
    Murphy, Angus Auxin-related growth, Herbicide metabolism, and ABC transporter and metalloprotease structure/function
    Peer, Wendy A. Molecular physiology and evolution, flavonoids
    Rossmann, Michael G. Structure of picornaviruses, parvoviruses, alphaviruses and bacteriophages, fX174, f29, T4; molecular evolution
    Sahley, Christie L. Cellular and molecular analysis of learning; cellular response to neural injury
    Simpson, Garth J. Development of novel techniques and their application in addressing important problems at biological interfaces
    Staiger, Chris Cytoskeletal function during plant and fungal development and in response to environmental signals
    Stauffacher, Cynthia V. Macromolecular structure and assembly using X-ray crystallography; membrane associated proteins; enzyme structure and function
    Suter, Daniel M. Neuronal growth cone motility and guidance, cell adhesion and migration, cytoskeletal dynamics, signal transduction, nervous system development
    Thompson, David H. 1) development of transiently-stable lipid- and polymer-based carrier systems for targeted drug & gene delivery; 2) development of high-throughput methods for detecting membrane protein activity; 3) development of materials and methods for controlled adsorption and templated protein crystallization
    Watts, Val J. Signaling of G protein-coupled receptors with an emphasis on dopamine receptors and adenylate cyclases
    Zhou, Daoguo Salmonella typhimurium Type III secretion; actin cytoskeleton rearrangements and bacteria-host interactions


    Student Membership

    Training Groups are topic-oriented research groups consisting of faculty from multiple departments. Training groups are an administrative home for PULSe students, a student choice that impacts curriculum and research training activities.

     

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