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PULSe Home > Training Groups > Chromatin and Regulation of Gene Expression

Chromatin and Regulation of Gene Expression

Chromatin and Regulation of Gene Expression

Research Includes

  • Biochemistry
  • Chromatin
  • DNA Repair
  • Gene Expression
  • Genomics
  • Nucleic Acids
  • Transcription

  • Training Group Mission

    Students in this training group work with a diverse group of faculty who employ an extensive range of experimental approaches with the goal of understanding chromatin and regulation of eukaryotic gene expression. Recent advances in the identification of chromatin modifying proteins and in the elaboration of the “histone code hypothesis” illustrate the value of interdisciplinary approaches in gaining insights into this exciting area of research. Students also have the opportunity to examine the effect of chromatin on other DNA-based processes such as replication, recombination, and repair. All students receive broad training in genetic, biochemical, and genome-based approaches in analysis of these fundamental processes.

    Faculty Membership

    Faculty Research Area
    Anderson, John N. Control of eukaryotic gene expression and replication; DNA structure; virus evolution
    Andrisani, Ourania M. Transcription factor CREB (cAMP-response-element binding protein) in mechanisms of growth control and cellular differentiation
    Briggs, Scott D. Role of histone methylation in gene expression and oncogenesis
    Broyles, Steven S. Transcriptional regulation in poxviruses
    Cabot, Ryan Reproductive physiology and molecular biology
    Donkin, Shawn S. Biomolecular Nutrition and Physiology
    Fleet, James C. Regulation of mineral metabolism, molecular actions of vitamin D in calcium metabolism and cancer prevention, gene-environment interactions influencing bone/calcium metabolism or cancer
    Forney, James D. Regulation of differentiation in protozoa
    Gelvin, Stanton B. Mechanism of the transfer to and expression of the Agrobacterium tumefaciens Ti-plasmid in plant cells
    Irudayaraj, Joseph MK Single molecule fluorescence lifetime imaging and fluorescence correlation spectroscopic measurements of epigenetic modification of single living cells, Nanotools and Raman spectroscopy for detecting in vivo phosphorylation, mRNA, and Micro RNA.
    Jackson, Scott A. Comparative genomics; physical mapping; interphase nuclear architecture; soybean genetics
    Kane, Michael D. DNA microarray technology to investigate the genomic basis of disease, development, and drug toxicity
    Kirchmaier, Ann L. Epigenetic processes that mediate heritable modifications to chromatin
    Konieczny, Stephen F. Gene expression during mammalian development; cancer model systems
    Lelièvre, Sophie A. Understanding how the cell nucleus directs expression and stability of the genome and how tissue architecture influences nuclear organization. Identify tissue architectural factors (notably apical polarity) that contribute to cancer development.
    Lossie, Amy C. Genomics and epigenetics
    Ogas, Joseph P. Regulation of cell identity, signal transduction, chromatin remodeling
    Stein, Arnold Chromatin structure and gene regulation; biotechnology
    Taparowsky, Elizabeth J. Oncogene expression in eukaryotic cells
    Tran, Elizabeth J The Mechanism of Nuclear Messenger RNA Export
    Weil, Clifford F. Maize genetics, genomics, value-added traits


    Student Membership

    Training Groups are topic-oriented research groups consisting of faculty from multiple departments. Training groups are an administrative home for PULSe students, a student choice that impacts curriculum and research training activities.

     

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