Purdue University PULSe
PULSe News
Drug studied as possible treatment for spinal injuries
Researchers have shown how an experimental drug might restore the function of nerves damaged in spinal cord injuries by preventing short circuits Read more...
New effort probes how two groups of viruses cause disease
Purdue University is leading a team of researchers in a federally funded effort aimed ultimately at developing better vaccines and antiviral drugs Read more...
Findings show nanomedicine promising for treating spinal cord injuries
Researchers at Purdue University have discovered a new approach for repairing damaged nerve fibers in spinal cord injuries using nano-spheres that Read more...
Enzyme may be a key to Alzheimer's-related cell death
A Purdue University researcher has discovered that the amount of an enzyme present in neurons can affect the mechanism thought to cause cell death Read more...
Protein helps cells duplicate correctly, avoid becoming cancer
A Purdue researcher has discovered that the absence of certain proteins needed for proper cell duplication can lead to Read more...
Purdue to dedicate Hockmeyer Hall of Structural Biology
Purdue University structural biologists - a group that provides insights that lead to vaccines and other disease treatments - are getting a booster Read more...
Dow AgroSciences, Purdue, IEDC partner for life sciences venture at Purdue Research Park
A new development project in the life sciences arena was announced Wednesday (Sept. 30) as part of a new agricultural collaboration among Dow Read more...

PULSe Home > Training Groups > Chemical Biology

Chemical Biology

Chemical Biology

Research Includes

  • Biocatalysis
  • Cellular Regulation
  • Drug Delivery
  • Drug Discovery
  • Glycobiology
  • Lipid Biochemistry
  • Metalobiochemistry
  • Molecular Recognition
  • Protein Folding and Assembly
  • Protein Trafficking
  • Receptor Pharmacology

  • Training Group Mission

    Students who join this training group work with a diverse group of faculty that apply chemical-based approaches to further the understanding of living systems. Fundamental and technical advances in chemistry, biochemistry, and structural and molecular biology over the past several decades have provided unprecedented opportunities to probe living systems at a molecular level. These advances have led to the development of a rapidly growing multidisciplinary field - Chemical Biology. Within the Chemical Biology training group, students apply groundbreaking chemical methodology to the elucidation of essential biological processes. Additionally, students that have identified new biological targets will drive the development of unique chemical entities. All students receive broad training at the interface of chemistry and biology, allowing the student to master the concepts needed for success in this multidisciplinary area of research.

    Faculty Membership

    Faculty Research Area
    Abu-Omar, Mahdi M. Reaction chemistry of transition element compounds, with particular emphasis on their role in molecular and biological catalysis
    Bergstrom, Donald E. Medicinal and bioorganic chemistry of nucleic acids
    Bolin, Jeffrey T. Protein structure and function; X-ray crystallography; metalloenzymes; biodegradation of PCBs and related compounds
    Borch, Richard F. Anticancer drugs: design, synthesis, and mechanisms of action
    Chmielewski, Jean A. Development of small molecules, peptides and peptidomimetics for drug discovery, bionanotechnology, and cellular delivery of therapeutic agents
    Cushman, Mark Design and synthesis of molecules that interact with enzymes and membrane-bound receptors
    Davisson, V. Jo Natural product drug discovery, chemical biology, bionanotechnology, microbial biodiversity
    Ghosh, Arun K. Synthetic organic, bioorganic and medicinal chemistry
    Gibbs, Richard A. Medicinal and bioorganic chemistry, synthesis and mechanistic evaluation of anticancer drugs
    Golden, Barbara Structural basis for RNA function
    Hrycyna, Christine A. Multidrug resistance in human cancer
    Hu, Chang-Deng AP-1 in human cancers and C. elegans development
    Kappock, T. Joseph Enzyme mechanism; acetic acid bacteria
    Lill, Markus A. Computer-assisted drug design
    Lipton, Mark A. Organic synthesis, bioorganic chemistry and molecular modeling
    Parker, Laurie L. Chemical biology and proteomics to develop biosensors for intracellular phosphorylation signaling
    Regnier, Fred E. Systems for the analysis and characterization of complex protein mixtures using multidimensional separation systems and mass spectrometry
    Rochet, Jean-Christophe (Chris) Protein misassembly diseases
    Savinov, Sergey N. Orthogonal antitumor, antiviral, and antibacterial strategies proteolysis
    Shah, Kavita Identification of the substrates of protein kinases, interplay between kinases and the activation and recruitment of downstream effector proteins
    Thompson, David H. 1) development of transiently-stable lipid- and polymer-based carrier systems for targeted drug & gene delivery; 2) development of high-throughput methods for detecting membrane protein activity; 3) development of materials and methods for controlled adsorption and templated protein crystallization
    Wei, Alexander Organic synthesis, nanostructured materials science, self-assembly principles to produce exotic materials with physical or biomimetic function
    Wilker, Jonathan Elucidating new roles for metals in biology, biochemistry, inorganic chemistry, polymer chemistry, marine biology, and materials engineering


    Student Membership

    Training Groups are topic-oriented research groups consisting of faculty from multiple departments. Training groups are an administrative home for PULSe students, a student choice that impacts curriculum and research training activities.

     

    PULSe Links:
    Request PULSe Info | Apply to PULSe
    Purdue Links:
    Purdue Homepage | Purdue Search | Campus Map | Purdue Directories

    PULSe, Purdue Graduate School Ernest C. Young Hall, Rm. B80
    155 S. Grant Street, West Lafayette, IN 47907 Phone: 765-494-9256
    Copyright ©2008, Purdue University, all rights reserved
    An equal access/equal opportunity university



    Pulse Administration System Purdue University