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PULSe Home > Faculty Members D-F > Edward Fox
Edward A. Fox
Current Research Interests:
How do we make decisions about what we eat - how much we eat, when we eat, or how often we eat? One neural system important in making these decisions is the component of the autonomic nervous system carried by the vagus nerve. Currently, a major focus for us is the sensory component of the vagus nerve because it is one of the most significant inputs for regulating metabolism and food intake. Traditional methods have not provided a means for independently manipulating the numerous vagal sensory pathways to determine their functions. Thus, we are taking advantage of mouse genetics and transgenic technology in combination with nerve mapping, immunohistochemical methods, and sophisticated behavioral methods to dissect the functions of these pathways.
Selected Publications:
Fox, E. A. & Byerly, M. S. (2004). A mechanism underlying mature onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutant mice. American Journal of Physiology, 286, R994-R1004.
Chi, M. M., Fan, G. & Fox, E. A. (2004). Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice. American Journal of Physiology, 287, R1044-R1053.
Fox, E. A., Phillips, R. J., Byerly, M. S., Baronowsky, E. A., Chi, M. M. & Powley, T. L. (2002). Selective loss of vagal intramuscular mechanoreceptors in mice mutant for steel factor, the c-Kit receptor ligand. Anatomy and Embryology, 205, 325-342.
Fox, E. A., Phillips, R. J., Baronowsky, E. A., Byerly, M. S., Jones, S. & Powley, T. L. (2001). Neurotrophin-4 deficient mice have a loss of vagal intraganglionic mechanoreceptors from the small intestine and a disruption of short-term satiety. Journal of Neuroscience 21:8602-8615.
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