PULSe Home > Faculty Members A-C > Ji-Xin Cheng

Assistant Professor of Biomedical Engineering and Analytical Chemistry Ph. D., 1998, University of Science and Technology of China. Contact Info: jcheng@purdue.edu 765-494-4335 Training Group(s): Membrane Biology

Current Research Interests:

A big challenge in the post genome era is to understand how proteins, nucleic acids, lipids, and other molecules work together inside a living cell. We are developing chemically selective imaging methods and investigating physical chemistry principles underlying various cellular processes using the new developments and other cutting edge technologies.

We study a variety of biological processes using linear and nonlinear optical microscopy. The topics include Organization of lipids and proteins in membranes; Nonlinear optical imaging of myelin sheath, demyelination, and spinal cord injury; delivery of nano drug carriers into cancer cells; Imaging stent drug distribution and release; in vivo imaging; intracellular trafficking.

Selected Publications:

H. Wang, Y. Fu, P. Zickmund, R. Shi, J. X. Cheng, "Coherent anti-Stokes Raman scattering imaging of live spinal tissues", Biophys. J., in press, 2005.

A. P. Kennedy, J. Sutcliffe, J. X. Cheng, "Molecular composition and orientation of myelin figures characterized by coherent anti-Stokes Raman scattering microscopy", Langmuir, in press, 2005.

J. X. Cheng and X. S. Xie, "Coherent anti-Stokes Raman scattering microscopy: Instrumentation, Theory, and applications", J. Phys. Chem. B, feature article, 108, 827-840 (2004).

Ji-Xin Cheng, S. Pautot, D. A. Weitz, X. S. Xie, "Ordering of water molecules between phospholipid bilayers visualized by coherent anti-Stokes Raman scattering microscopy", Proc. Natl. Acad. Sci. USA, 100, 9826-9830 (2003).

Ji-Xin Cheng, Kevin Y. Jia, Gengfeng Zheng, X. Sunney Xie, "Laser-scanning coherent anti-Stokes Raman scattering microscopy and applications to cell biology", Biophys. J. 83, 502-509 (2002).

Ji-Xin Cheng, Andreas Volkmer, X. Sunney Xie, "Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy", J. Op. Soc. Am. B, 19, 1363-1375 (2002).