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Assistant Professor of Cancer biology, Director of Purdue Cancer Center Drug Discovery Shared Resource D.V.M. --Khartoum University M.S. ---Cornell University Ph.D. --- Purdue University Contact Info: mohammes@purdue.edu 765-494-9948 Training Group(s):

Current Research Interests:

My current research focuses on identification of specific and sensitive biomarkers for early detection of cancer. We employ in our research Laser capture microdissection (LCM), proteomics and nanotechnologies. A tumor biopsy contains many cell types other than tumor cells such as normal and activated endothelial cells, macrophages, and fibroblasts. LCM allows us to procure pure populations of neoplastic cells or normal cells and compare them either at the DNA, RNA or protein level. Since any cell phenotype is determined by its proteins composition and the activation status of its proteins, we used 2-dimentitonal gel electrophoresis, protein finger printing, and databases to determine differences in proteins expression profiles between tumor and normal cells and to identify differentially expressed proteins. These proteins can be used as biomarkers for early detection and as targets for therapeutic intervention