|
PULSe Home > Faculty Members A-C > Jue Chen
Jue Chen
Current Research Interests:
We are using biochemical and biophysical methods, X-ray crystallography in particular, to investigate how proteins carry out their functions.
Our lab aims to determine the 3D structure of an important group of membrane traffic proteins called ATP-binding Cassette (ABC) transporters. Improving our understanding of membrane transport mechanisms has great medical impact, as some ABC proteins are related to severe diseases such as cystic fibrosis, hyperinsulinemia, hypoglycemia, macular degeneration and cancer. We are also studying a group of membrane fusion proteins to understand how viruses get into the cell. This research will provide information to combat diseases caused by viral infection.
Selected Publications:
Davidson A. L. and Chen, J. 2004 ATP-binding cassette transporters in bacteria. Ann Rev Biochem. 73:241-268.
Chen, J.; Lu G.; Lin J.; Davidson A. L.; and F. A. Quiocho. 2003. A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle. Mol. Cell, 12:651-661.
Samanta, S.; Ayvaz, T.; Reyes, M.; Shuman, H.A.; Chen, J.; and A.L. Davidson. 2003. Disulfide crosslinking reveals a site of stable interaction between C-terminal regulatory domains of the two MalK subunits in the maltose transport complex. J Biol Chem., 278:35265-35271.
Chen, J., S. Sharma, F. A. Quiocho, and A. L. Davidson. 2001. Trapping the transition state of an ABC transporter: evidence for a concerted mechanism of maltose transport. Proc. Natl. Acad. Sci. USA 98:1525-1530.
|
